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Topiramate is also used to prevent migraine headaches in adults.

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Some subjects may experience a large increase in amitriptyline concentration in the presence of topiramate and any adjustments in amitriptyline dose should be made according to the patient"s clinical response and not on the basis of plasma levels.

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Significantly lower maternal body weight gain was recorded at these doses in rats and rabbits.

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Measure electrolytes including serum bicarbonate, potassium, creatinine, blood glucose (in diabetics), BP (in patients on antihypertensives) prior to starting and during therapy.

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