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This requirement should be referenced and enforced through relevant policies, standards and guidelines issued by professional pharmacy bodies.
Key exclusion criteria included a history of uncontrolled hypertension or seizure disorder, anemia attributable to another cause, and exposure to any epoetin within 3 months.
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Celltrion has an ongoing phase I study designed to demonstrate comparable pharmacokinetics between their biosimilar (CT-P10) and rituximab in patients with active rheumatoid arthritis (identifier: NCT01534884).
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If effective a setron may be used as a preventative therapy during the next cycle of chemotherapy.
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Although epoetin alfa and darbepoetin alfa, a related erythropoiesis-stimulating agent (ESA) approved in 2001, have been widely accepted for this indication, optimal hemoglobin targets have never been established.
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