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Relapse rates before and during treatment with amisulpride were calculated in accordance to an increase of 1 or more in Clinical Global Impressions Scale-Bipolar Version (CGI-BP) score that was accompanied by a change in therapy or to an exacerbation of the symptoms that required hospitalization.

The widespread use of antipsychotic drugs over the past decade does not appear to have had much effect on suicide rates.

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In contrast, D 2-like receptor stimulation results in decreased AC activity, generating “downstates” (Hernandez-Lopez et al.

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In elderly patients, amisulpride therapy, like other neuroleptics, should be used with particular caution because of a possible risk of hypotension or sedation.

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Patients with advanced stages of the illness are often treated with chlorambucil, fludarabine, or other cytotoxic agents, often with rituximab (a monoclonal antibody) added to enhance response.

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The data represent the mean changes from baseline on the Simpson-Angus Scale (SAS) after initiation of treatment with the indicated doses of amisulpride or haloperidol.

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In 2005 the US government body published the results of a major independent (not funded by the pharmaceutical companies) multi-site, double-blind study (the CATIE project).

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Psychosocial intervention component, objective A: drug adherence rates as a function of (standardized self report and) Sellwood rating scales after 12 and 52 weeks.

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It is reported in the UKPAR (Special Warnings and Precautions for Use) that amisulpride induces a dose dependent prolongation of the QT interval.

Borison RL, Schooler NR, Chouinard G: A path-analytical approach to differentiate between direct and indirect drug effects on negative symptoms in schizophrenic patients: a re-evaluation of the North American risperidone study.

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Some forms of depression are related to a decreased responsiveness of 5-HT1A receptors, as suggested by studies employing a 5-HT1-mediated neuroendocrine model.

The authors present the clinical response from using Amisulpride in three Clozapine-resistant schizophrenic patients.

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Patients and healthcare professionals urgently need new and improved interventions in these rapidly expanding, yet poorly served, areas of supportive care, to improve treatment outcomes and patients' quality of life.

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If you do make changes to your prescribed therapy course, you can risk worsening your initial medical status, besides compromising your treatment.

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Although major life events often precede depression, the antecedents of affective illness may involve a series of minor stressors (day-to-day hassles).

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It was also alleged that the company conducted so-called "seeding studies" that were, in reality, marketing efforts to promote the drug's use by doctors.

Carta and coworkers reported positive outcomes using amisulpride as adjunctive long-term pharmacotherapy in 14 bipolar I patients.

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In support of modafinil acting as a dopaminergic agent, its wakefulness-promoting effects are abolished in DAT (although it is important to note that DAT knockout mice show D 1 and D 2 receptor and norepinephrine compensatory abnormalities, which might confound this finding), reduced by both and (although conflicting reports exist), and completely blocked by simultaneous inactivation of both D 1 and D 2 receptors.

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An analysis of the data on the patients who completed the study confirmed the results of the intent-to-treat analyses ().

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MT2 receptors and as a competitive antagonist at serotonergic 5-HT2C-receptors, regulates circadian rhythms and enhances sleep patterns which are frequently disturbed in schizophrenic patients; but further investigations are necessary, before any recommendations in schizophrenic populations can be made.

The Discussion section is about the clinical approach to the use of atypical antipsychotics, which takes into account the different guidelines, possible comorbidities, and the many practical problems in the treatment of elderly patients.

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Adverse effects: Moderate to high quality evidence suggests amisulpride was associated with less weight gain than risperidone or olanzapine and agitation may be reported more often for amisulpride.

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Over the past two decades, second-generation antidepressants have gradually replaced first-generation antidepressants, such as (TCAs) and (MAOIs) as the drugs of choice for the treatment of MDD.

Carbamazepine is a widely used in patients who have not responded to treatment with lithium, especially in Europe and Japan.

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In conclusion, dopamine agonist therapy is not generally advisable (), even though successful cases are reported of risperidone-induced hyperprolactinemia treated with the addition of either cabergoline or bromocriptine, without worsening psychotic symptoms ().

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